Two people are said to be stuck in the building.
They are said to be alive and still communicating with friends and relatives.
Police fire brigade was called to fight the fire whose cause is yet to be established.
QFm is a community radio station based in Lira Town. It is located on Ayer Road Plot 11B.
The building that has caught fire houses several offices including a law firm–Makmot Kibwanga & Company Advocates.