Devolution Cabinet Secretary Anne Waiguru has resigned.
Fearing, and concerned for her health, the emotional Ms Waiguru said she had taken the decision on the advice of her doctor.
The beleaguered CS, who has scooped various awards, said the war against graft had turned out to be attacks on her.
Following her doctor’s advice, Ms Waiguru said she had asked President Uhuru Kenyatta to relieve her of her duties at the ministry.
She outlined the achievements the ministry she has led since 2013 has made before announcing that the experience at the State office had caused her great pain as well as her family.
Her health, she said, has also been affected and thus due to her poor condition as a result of constant attacks on her person and family, she had decided to throw in the towel.
And as her critics mounted pressure every day on her to leave office over rife corruption in her ministry, her supporters painted her as a victim of her success.
In July, the embattled CS ruled out stepping aside over the National Youth Service (NYS) scandal.
Speaking on Citizen TV, Ms Waiguru said people do not step aside because they have been told to do so on the street.
“How can they ask me to step aside when I blew the whistle? I’m the one who called CID,” said the CS, adding that just because an organisation has been touched by corruption doesn’t mean that its head must resign.
Ms Waiguru during the live TV show, also denied claims that she is a “super Cabinet Secretary”; that is, the most powerful CS in government.
She also rejected allegations that she is arrogant and pushy.
“In my line of work, one is bound to rub some people the wrong way. This is often the cause of these allegations,” said Ms Waiguru said then.