Kampala Capital City Authority (KCCA) football club edged rivals Sports Club Villa Jogoo 1-0 at Nakivubo Stadium.
Second half substitute Sulaimon Akimenyi scored the lone strike on the day.
KCCA now has 55 points from 28 games played, five ahead of second placed Vipers.
The Saints ease their relegation woes with a slim 1-0 victory over Maroons at the Nelson Mandela National Stadium.
Goalkeeper Yasin Mugabi, on loan from KCCA scored the winning penalty.
At the Kakindu stadium in Jinja, Vipers and host club, JMC Hippos played to a one all draw.